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HIV NUTRITION UPDATE
VOLUME 7, ISSUE 1
A PILOT INVESTIGATION OF THE MICROBIAL CONTAMINATION OF HERBAL SUPPLEMENTS: IS THERE A RISK FOR IMMUNOCOMPROMISED POPULATIONS?
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Under the DSHEA, manufacturers of dietary supplements can make claims about how their products affect the structure of the body, but not claims that they can cure, treat, diagnose, or prevent a disease. (6) The current law allows for the commercialization of herbal supplements without the FDA's rigorous safety and efficacy tests that are required to be performed on drugs, before they are released to the public. (6-10) Recent research has demonstrated the lack of regulation of herbal supplements. Norton recently noted in the New England Journal of Medicine the presence of raw animal tissues as ingredients in a number of dietary supplements and their potential risk. (11) Herbal supplements have been shown to vary widely in their actual dosage. (12) Other recent evaluations of supplements have indicated that the herb was either missing from a supplement or found in very small amounts. (13)

Potential harmful interactions between herbs and drugs have been examined. (14) Herbal products that have been adulterated with prescription drugs have been identified. (15) Chinese herbal medicinal plants have been shown to contain a high level of toxic heavy metals, such as lead, zinc, mercury and cobalt and disturbing reports of toxic herbs being incorrectly identified have occurred. (16-17)

Lack of regulation for herbal supplements presents another potential danger, which is contamination with microorganisms. Surprisingly, only a few surveillance studies have been conducted to assess this threat. Fungi have been cited as a source of contamination in some herbal products. Mycotoxins from Aspergillus flavus were detected in commercial herbal tea samples and medicinal plants. (18) Penicillium, Rhizopus, Mucor, Cladosporam, and Auerobasidium sp were found in powdered herbal drug samples. (19) Evidence of human contamination of herbs has also been reported. The source of a hepatitis E infection in a Japanese man was determined to be a Chinese herbal medicine. (20)
 
 

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7/23/2002